Table 2.

Methylation levels of the seven CGIs in H. pylori–negative and H. pylori–positive individuals and in healthy volunteers and gastric cancer cases

nMean ageCorpus
Antrum
p16 (core)p16 (non)LOXFLNcHRASLSHAND1THBDp41ARCp16 (core)p16 (non)LOXFLNcHRASLSHAND1THBDp41ARC
HV
    HP(−)56510.0%0.1%1.2%0.0%0.1%0.8%1.0%2.1%0.0%0.1%1.2%0.1%0.1%1.1%0.8%1.9%
    HP(+)98570.9%2.2%16.0%2.3%1.3%7.4%10.7%11.2%1.1%2.6%18.8%2.2%1.5%8.8%14.2%10.7%
    P<10−8<10−9<10−17<10−10<10−17<10−16<10−17<10−14<10−8<10−10<10−19<10−13<10−19<10−18<10−19<10−14
GCC
    HP(−)29690.2%0.6%8.2%0.6%0.6%4.1%7.1%6.6%0.2%0.5%4.6%1.3%0.4%7.5%5.5%4.9%
    HP(+)43670.4%2.0%12.7%0.8%1.2%8.1%12.3%11.5%0.3%2.5%11.2%1.0%0.8%11.3%10.2%7.8%
    P0.07<0.010.020.17<0.01<0.010.01<0.010.280.04<0.010.350.020.050.020.02
HP(−)
    AM-HV29630.0%0.2%1.7%0.1%0.1%1.0%1.3%3.1%0.0%0.2%1.4%0.1%0.1%1.7%1.1%2.2%
    GCC29690.2%0.6%8.2%0.6%0.6%4.1%7.1%6.6%0.2%0.5%4.6%1.3%0.4%7.5%5.5%4.9%
    P<0.010.01<0.01<0.01<0.010.01<0.01<0.010.050.020.020.03<0.01<0.01<0.010.02
HP(+)
    AM-HV43641.0%1.9%12.8%1.4%1.2%6.7%9.4%9.4%0.8%2.1%13.9%1.5%1.2%7.8%10.0%9.8%
    GCC43670.4%2.0%12.7%0.8%1.2%8.1%12.3%11.5%0.3%2.5%11.2%1.0%0.8%11.3%10.3%7.8%
    P0.030.440.480.020.480.130.070.110.070.380.170.090.050.020.450.12
  • Abbreviations: HV, healthy volunteers; GCC, gastric cancer cases (noncancerous mucosae); AM-HV, age-matched healthy volunteers; non, noncore.