Table 2.

Cross-resistance profile of depsipeptide-selected cell lines

DrugS1S1 DP50Relative resistanceSW620SW620 DP50Relative resistance
Depsipeptide0.5 ± 0.03450 ± 719000.5 ± 0.2150 ± 71300
Adriamycin0.01 ± 0.0080.2 ± 0.07200.03 ± 0.0040.4 ± 0.113
Paclitaxel0.01 ± 0.0050.6 ± 0.5600.004 ± 0.00070.1 ± 0.00725
Vinblastine0.001 ± 0.00070.04 ± 0.04400.002 ± 0.0010.04 ± 0.0220
  • NOTE: IC50s are in μmol/L, except for depsipeptide values, which are in ng/mL. Relative resistance values were calculated by dividing the IC50 of the selected cell lines by the IC50 of the respective parental cell lines.