Table 4.

Individual markers or clinical variables as predictors of survival

VariableRelative hazard for death (95% confidence interval)P (log-rank)
Treatment arm1.65 (0.73, 3.8)0.22
Bisphosphonate use (yes/no)0.78 (0.31, 2.0)0.59
Performance status (≥90/<80)0.66 (0.29, 1.5)0.31
Prior chemotherapy (yes/no)2.38 (0.9, 5.8)0.06
Gleason score (>8/≤8)1.03 (0.4, 2.4)0.95
Hemoglobin (>/≤ median)0.11 (0.03, 0.67)<0.001
PSA level* 6.47 (2.2, 19.2)<0.001
Total alkaline phosphatase* 5.94 (1.9, 17.9)<0.001
N-Telopeptide*6.50 (2.2, 19.1)<0.001
Deoxypyridinoline* 5.43 (2.0, 14.7)<0.001
Pyridinoline*1.43 (0.6, 3.2)0.38
Osteocalcin*1.48 (0.6, 3.4)0.34
PINP* 6.30 (2.2, 18.5)<0.001
PIIINP* 3.51 (1.4, 8.9)0.0045
  • * Baseline values dichotomized at the median (i.e., ≤ vs > calculated median value).

  • Baseline values above the median were significantly associated with an increased hazard for death.