Table 3.

Clinical toxicities observed with hu14.18-IL2

Dose (mg/m2/d)n*No. coursesNumber of patients with the highest toxicity observed in all courses of therapy
Fever grade
Rigors grade
Hypotension grade
Hypoxia grade
Pruritus grade
Pain grade
Fatigue grade
234234234234234234234
2620241121
43912222
637321
84122232112
1031012132
12612311121241
14.43612121111
  • NOTE: Clinical toxicities graded 1 to 4 as per National Cancer Institute Common Toxicity Criteria, version 2.0.

  • * Total number of patients treated at each dose level.

  • Total number of courses administered for all patients at the indicated dose level.

  • For each category of toxicity, each patient was scored based on their highest grade of toxicity for each course of treatment. For each dose level of hu14.18-IL2, the number of patients showing each grade of toxicity as their highest grade is shown.