Table 6.

DLTs observed during treatment with hu14.18-IL2

Dose (mg/m2/d)Total no. patientsNo. patients evaluable for toxicityDLT during course 1 (no. patients)DLT during courses 2-4 (no. patients)
266Neutropenia (1)Hematuria (1)
433NoneNone
633NoneNone
843NoneHypotension (1)
1033NoneNone
1266Allergic reaction (1)Blurred vision (1), thrombocytopenia and hypotension (1), rash (1)
14.433Delayed neutropenia and leukopenia (1)None
  • NOTE: Not all grade 3 toxicities were scored as DLT, such as transient hypotension not requiring pressors (see Patients and Methods).