Table 2.

Adverse events caused by BMS-275183 (any cycle)

Grades 1-2Grade 3Grade 4
Hematologic
    Neutropenia1235
    Anemia94
    Thrombocytopenia11
Neurology
    Sensory neuropathy265
    Motor neuropathy162
    Ataxia3
    Dizziness4
Gastrointestinal
    Nausea14
    Vomiting13
    Anorexia111
    Stomatitis/mucositis5
    Constipation51
    Diarrhea104
    Taste disturbance5
Hypersensitivity1
Pain
    Arthralgia121
    Myalgia10
    Abdominal pain61
Cardiac
    Palpitations2
    QTc prolongation2
Other
    Fatigue1461
    Alopecia26
    Fever10
    Skin rash5
    Epistaxis11
    Petechiae/purpura2
    Edema3
    Cough1
    Nail changes3
    Bruising2
    Voice changes2
  • NOTE: Events considered possibly, probably, or certainly related to BMS-275183 by the treating physician and the investigator are presented. Several episodes in the same patient are counted as one adverse event and only the worst grade is mentioned (48 patients treated with 5 mg to 320 mg/m2).