Table 3.

Pharmacokinetic variables for BMS-275183 (first dose)

Dose (mg/m2)
5 mg510204080120160200240320
No. of patients1*2*1*1*1*1*66212*6
Cmax (ng/mL)2.115.641.556.3313311240 (105)989 (611)817 (372)1,6131,194 (483)
Tmax (h)1.50.751.01.00.51.01.0 (0.5-1.0)1.0 (1.0-1.5)1.0 (0.5-3.0)1.51.0 (1.0-2.0)
AUC (INF) (ng/h/mL)23.11054442761,0181,1911,344 (759)4,968 (2,959)4,485 (2,387)6,1596,503 (1,909)
T-half (h)26.218.920.918.625.225.126.2 (4.1)21.8 (7.8)22.4 (11.2)18.717.0 (1.8)
  • * SD and range not presented because n ≤ 2.

  • Mean (SD).

  • Median (range).