Table 2.

Phenotypic characteristics and signaling capability of IgG+ CLL B cells

CaseL chainsIgG MFIiIgG MFI%CD38+%CD69%ZAP-70Ca2+ fluxp72Syk P-Tyr*
1λ18ND2240++
2κ12381710++
3κ32ND94394++
4κ8342131
5λ44182100256+ND
6κ7467681158+ND
7κ42310216
8κ395424412+ND
9κ525926
10κ10390231+ND
11κ5511215ND
12κ85001311ND
13κ69ND932335+ND
14κ11441361++
  • Abbreviations: sIgG, surface IgG; ilgG intracellular IgG; p72Syk; ND, not done.

  • * Tyrosine phosphorylation of p72Syk as determined by immunoprecipitation and immunoblotting.