Table 3.

Heavy and light chain gene V-gene segment analysis

PatientVHD (reading frame)JH% VH homologyIgG subclassCDRH3 sequenceLCVL*JL%VL homology
13-07693.52DGETVVVWLARVSGG MDVλIGLV10-54 (10a)395.5
23-07391.23DLPGSGYWWRDA FDMκIGKV1-9 (L8)297.9
33-232-02 (RF2)695.31RNLLRCSSTSCYGD YYGMDVκIGKV2-28 (A19/A3)498.6
43-30.3491.82WAGSWAGTWPIVGL FDYPκIGKV3-15 (L2)294.1
53-30.3493.91DEGGRGAGGGG FDYλIGLV3-25 (3m)297.3
63-30.54-4/11 (RF3)289.11EGSSVTTSSKRF AFDIκIGKV3-11 (L6)397.5
73-64494.21DTQWLVK YκIGKV2-28 (A19/A3)198.2
84-34492.43REGYQLV YκIGKV1-39 (O2/O12)296.1
94-344-17 (RF2)691.01GYGDSATYKR YYYYGMDVκIGKV2-30 (A17)295.7
104-345-05 (RF1)693.82GYGVDPTIRR YYYYGMDVκIGKV2-30 (A17)297.7
114-345-05 (RF1)692.11GYGDTIDIKR YYYYGMDVκIGKV2-30 (A17)298.0
124-346-13 (RF1)690.71GWGSSSQIRR YYYYGMDVκIGKV2-30 (A17)297.7
134-396-13 (RF1)51001RDGISSSWYTKKA WFDPκIGKV1-39 (O2/O12)4100
144-59594.52DFYYGDPRG WFDTκIGKV1-39 (O2/O12)292.8
474-34GFPDTDVIKR YYYYGFDV
CLL1834-34GYGDTPTIRR YYYYGMDV
CLL2404-34GYADTPVFRR YYYYGMDV
CLL3424-34GWGDTPMLKR YYYYGLDV
  • NOTE: Amino acids encoded by D gene segments are underlined.

  • * VL nomenclature: the IMGT nomenclature for (54) and (55) genes is used with the Zachau (Vκ; ref. 56) and the Frippiat et al. (Vλ; refs. 57, 58) nomenclatures followed in brackets.

  • Data from ref. 41 (cases from the literature).