Table 1.

Erlotinib and OSI-420 pharmacokinetic variable summary statistics

Smoking statusDose (mg)Erlotinib
OSI-420
Cmax (ng/mL)Tmax (h)C24h (ng/mL)AUC0-∞ (ng·h/mL)T1/2λz (h)Cmax (ng/mL)Tmax (h)C24h (ng/mL)AUC0-∞ (ng·h/mL)T1/2λz (h)
Nonsmokers150 (n = 16)Median1,055233220,5779.4069.6217.31,10212.5
Minimum655171.28,2593.9343.513.395046.31
Maximum1,470648928,76616.698.3625.51,61614.9
Geometric mean1,05628818,72667.914.51,037
300 (n = 12)Median2,085277343,59111.7134244.32,56011.7
Minimum1,300137425,3526.6385.8120.09498.97
Maximum2,75041,61085,57320.732061196,09227.7
Geometric mean1,97977644,31714346.42,602
Smokers150 (n = 16)Median950257.77,7124.2555.024.145285.75
Minimum12411.251,0052.116.6411.1967.52.34
Maximum1,360622815,3259.3579.0612.91,795391
Geometric mean68934.86,71841.24.41469
300 (n = 14)Median1,795225919,6764.78123213.21,1797.22
Minimum632135.19,0292.6735.412.595324.26
Maximum2,730847929,70110.91741239.12,46318.0
Geometric mean1,57722919,05010212.81,175