Table 2.

Xenograft gene alterations and radiation sensitivities

XenograftControl survival*RT survival*PEGFR statusp53 status§PTEN status§p16 status§
6651160.01+v IIIMutantwtNull
146289<0.01wtNullNull
155299<0.01+wtwtwtNull
2841530.04MutantMutantwt
3861680.01+wtMutantwtNull
3988>135<0.01+v IIIwtwtNull
882900.49+wtwtNullNull
1041390.95wtNullNull
1236410.35+wtNullwtNull
3667620.57MutantNullNull
4324240.19MutantwtNull
4465620.52wtwtNull
4651530.40+v IINDNDNull
  • * Control/placebo and radiation treatment (RT) survivals represent median values in days.

  • P values indicated are based on Kaplan-Meier survival analysis.

  • Tumors with EGFR amplification are indicated with “+” and amplified tumors are either indicated as wild-type (wt), vIII mutant, or vII mutant.

  • § p53, PTEN, and p16 status are either normal/wild-type (wt), missense mutant (mutant), or mutant with lack of detectable protein (null).