Table 3.

Radiosensitivity effects associated with regimen modifications

XenograftRadiation regimenSurvival differential* (d)P
812 Gy/12 d80.78
820 Gy/5 d00.40
1012 Gy/12 d−2,0.95
1012 Gy/12 d−2,§0.10§
1012 Gy/2 d2§0.64§
1020 Gy/5 d30.07
1212 Gy/12 d50.35
1212 Gy/12 d1§0.43§
1212 Gy/2 d6§0.05§
1220 Gy/5 d15<0.01
1412 Gy/12 d27<0.01
1412 Gy/12 d42§<0.01§
1412 Gy/2 d22§<0.01§
1420 Gy/5 d38<0.01
1512 Gy/12 d47<0.01
1512 Gy/12 d147§<0.01§
1512 Gy/2 d156§<0.01§
4312 Gy/12 d00.19
4320 Gy/5 d160.02
4412 Gy/12 d−3,0.52
4420 Gy/5 d−30.92
  • * Survival differentials represent the difference in median survival for control versus radiation treatment arms. All experiments had between 7 and 10 animals per group.

  • Denotes results from the initial 12 Gy/12 day survival comparison (Table 2), which are shown here to facilitate comparison with results from subsequent experiments.

  • Negative numbers denote instances in which the median survival of the radiation treatment group was less than that of the control group.

  • § Denotes results from experiments in which there were both 12 Gy/12 day and 12 Gy/2 day.