Table 3.

Proliferation indices by EGFR and/or HER-2 positivity (worst tissue samples)

EGFR/HER-2 status, average % positivity (SD)*
Ptrend
EGFR−/HER-2− (n = 10)Mixed (n = 28)EGFR+/HER-2+ (n = 96)§
Ki-678.70 (11.37)30.27 (29.60)49.91 (27.51)0.00001
MCM258.90 (30.84)66.23 (36.03)87.91 (19.50)0.00056
  • * EGFR+ (EGFR−) denotes a sample that is positive (negative) for EGFR overexpression; HER-2+ (HER-2−) denotes a sample that is positive (negative) for HER-2 overexpression.

  • Test for a linear trend across the HER-2−/EGFR−, mixed, and HER-2+/EGFR+ categories.

  • Mixed denotes either HER-2+/EGFR− or HER-2−/EGFR+.

  • § n = 95 for Ki-67.