Table 4.

Response to gefitinib in patients without EGFR mutation

Total no.No. responders (%)P*
EGFR gene copy number
    Low copy number312 (6.5)0.10
    High copy number215 (23.8)
K-ras
    Mutation (−)478 (17.0)0.58
    Mutation (+)70 (0.0)
PTEN
    Reduced151 (6.7)0.42
    Intact397 (17.9)
Akt phosphorylation
    Negative/weak398 (20.5)0.089
    Strong150 (0.0)
Erk phosphorylation
    Negative195 (26.3)0.11
    Positive353 (8.6)
K-ras and Akt phosphorylation
    K-ras mutation (−) and p-Akt (−/1+)328 (25.0)0.016
    K-ras mutation (+) or p-Akt (2+)220 (0.0)
  • * Fisher's exact test.