Table 1.

Physiologic variables of rats treated with CDDP and/or cotreated with erythropoietin and carbamylated erythropoietin

GroupExperiment 1
Experiment 2
Baseline body weight (g)Final body weight (g)Hematocrit (%)Baseline body weight (g)Final body weight (g)Hematocrit (%)
Control + vehicle186 ± 2221 ± 351.9 ± 1.0184 ± 5255 ± 950.0 ± 1.8
CDDP + vehicle197 ± 3199 ± 3*47.5 ± 1.2181 ± 3212 ± 652.3 ± 1.1
Control + erythropoietin196 ± 2222 ± 382.4 ± 1.5
Control + carbamylated erythropoietin184 ± 3248 ± 656.4 ± 2.3
CDDP + erythropoietin195 ± 3209 ± 684.3 ± 1.2182 ± 5229 ± 776.2 ± 6.3§
CDDP + carbamylated erythropoietin180 ± 5230 ± 551.0 ± 1.3
  • NOTE: Data are mean ± SE (8 per group). Statistics by ANOVA with Tukey-Kramer HSD test for multiple comparisons.

  • * P < 0.01 versus control and control + erythropoietin (experiment 1).

  • P < 0.01 versus all the other groups (experiment 2).

  • P < 0.01 versus control and CDDP (experiment 1).

  • § P < 0.01 versus all the other groups (experiment 2).