Table 2.

Drug-related (probable or possible) toxicities

Dose levelNumber of patients
Grade 0Grade 1Grade 2Grade 3Grade 4
Cycle 1 only
    200 mg q.d. (n = 3)10110
    250 mg q.d. (n = 6)03210
    300 mg q.d. (n = 6)10320
    125 mg b.i.d. (n = 6)32010
    150 mg b.i.d. (n = 10)42211
    175 mg b.i.d. (n = 8)21410
Any cycle
    200 mg q.d. (n = 3)10110
    250 mg q.d. (n = 6)01230
    300 mg q.d. (n = 6)01320
    125 mg b.i.d. (n = 6)23010
    150 mg b.i.d. (n = 10)10621
    175 mg b.i.d. (n = 8)01070