Table 3.

Grade 3 or 4 toxicities possibly or probably related to ABT-751 during all cycles

ToxicityNumber of patients per dose level
q.d. regimen (mg)
b.i.d. regimen (mg)
200 (n = 3)250 (n = 6)300 (n = 6)125 (n = 6)150 (n = 10)175 (n = 8)
Asthenia010125
Constipation011023
Abdominal pain000001
Ileus011*01*0
Nausea000001
Neuropathy002*000
Paresthesia000011
Anemia100000
Prothrombin time elongation100000
Arthralgia000001
Myalgia000001
Fecal impaction000001
  • * Indicates DLT.