Table 2.

Number of patients treated at each dose level of each schedule and number of patients who experienced DLT at each dose level

Dose level (mg/m2)60-min infusion, q21 d
5-min bolus infusion, q21 d
5-min bolus infusion, weekly, 4 of 6 wks
No. patients treated, 9No. cycles, total (range), 16 (1-2)No. patients with DLTNo. patients treated, 16No. cycles, total (range), 38 (1-5)No. patients with DLTNo. patients treated, 5No. cycles, total (range), 7 (1-2)No. patients with DLT
10057 (1-2)2
200612 (2)36 (2)
30034 (1-2)2921 (1-3)1
400411 (2-5)2