Table 3.

Summary of nonhematologic toxicities during the study (worst grade, all courses)

ToxicityDose level (no. patients treated at this dose level)
60-min infusion
5-min infusion
Weekly
200 mg/m2 (n = 6)
300 mg/m2 (n = 3)
200 mg/m2 (n = 3)
300 mg/m2 (n = 9)
400 mg/m2 (n = 4)
100 mg/m2 (n = 5)
Grade 1/2Grade 3/4Grade 1/2Grade 3/4Grade 1/2Grade 3/4Grade 1/2Grade 3/4Grade 1/2Grade 3/4Grade 1/2Grade 3/4
Fatigue501220511132
Nausea402030504020
Vomiting301110403020
Fever102020603010
Rash112111213131
Pruritus001000312000
Anorexia101000403000
Headache100000212000
Chills000010101000
Flu syndrome101010000000
Tumour pain000000010000
Herpes simplex100000102000
Diarrhoea200000100020
Stomatitis000000101010
Somnolence000000001100
Raised creatinine000000010000
  • NOTE: Includes events occurring in >5% of patients or of severity grade >1.