Table 4.

Number of patients in each cohort who experienced an increase in fatigue following treatment with OSI-7836

ScheduleDose level (mg/m2)No. patients with fatigue/total no. patients treatedSeverity of fatigue
No increaseIncrease by one gradeIncrease by two gradesIncrease by three grades
60 min2005/61220
3003/31101
5 min2002/30200
3007/90322
4004/40211
Weekly1005/51121
Total no.26/3031175