Table 4.

Cox proportional hazard model for disease progression in bladder cancer

FactorCategoryHazard ratio (95% confidence interval)P
Univariate analysis
    CA+ vs −3.858 (1.745-16.388)0.0001
    20q13 gain+ vs −1.591 (1.017-2.562)0.0421
    DNA ploidyAneuploid vs diploid1.637 (1.039-2.695)0.0334
    Aurora-A overexpression+ vs −2.092 (1.207-4.343)0.0066
    Increased p53 immunoreactivity+ vs −1.816 (1.117-3.224)0.0150
    MMR protein expressionLow vs normalnot calculated (not calculated)0.0224
    Tumor shapeNonpapillary vs papillary2.093 (1.180-3.431)0.0142
    Tumor numberMultiple vs single1.765 (1.068-3.300)0.0254
    Tumor gradeG3 vs G2 and G15.592 (2.165-16.383)0.0003
    Tumor stagepT2 vs pT1 and pTa2.113 (1.288-3.325)0.0044
Multivariate analysis
    CA+ vs −3.562 (1.591-15.188)0.0005
    Tumor shapeNonpapillary vs papillary2.041 (1.131-3.429)0.0203
    Tumor stagepT2 vs pT1 and pTa1.728 (1.043-2.750)0.0346