Table 3.

Survival analysis in MPM patients

VariablesCategoriesUnivariate analysis
Multivariate analysis
HR (95% CI)PHR (95% CI)P
Tumor stage*0.058
Histologic subtypeEpithelioid
Biphasic0.91 (0.37-2.24)0.8480.943 (0.350-2.539)0.908
Sarcomatoid4.08 (1.72-9.66)0.0016.683 (2.525- 17.683)0.001
Serum mesothelin>3.5 nmol/L2.39 (1.247-4.583)0.0092.785 (1.384-5.607)0.004
Pleural mesothelinContinuous0.994 (0.988-1.001)0.118ND
Serum osteopontin>350 ng/mL5.263 (1.875-14.777)0.0023.459 (1.098-10.895)0.034
Plasma osteopontinContinuous1.001 (1.000-1.001)0.001ND
Pleural osteopontinContinuous1.0000.259ND
  • Abbreviation: ND, not done.

  • * Tumor stage was not retained as an independent prognostic factor in the multivariate analysis.