Table 2.

Silibinin levels in blood and colorectal or hepatic tissues of colorectal cancer patients who had received silibinin daily for 7 days as silipide capsules

Dose (mg/d)Peripheral blood levels (μmol/L)Colorectal tissue levels (nmol/g)
NormalMalignant
3600.3 ± 0.3*28 ± 3137 ± 51
7200.7 ± 0.6121 ± 18120 ± 26
1,4403 ± 2.3141 ± 16968 ± 98
Dose (mg/d)Blood levels (μmol/L)
Hepatic tissue levels (nmol/g)
Peripheral
Portal
Normal
Malignant
3600.4 ± 0.20.5 ± 0.31 ± 0.90.6 ± 0.5
7201.4 ± 10.5 ± 0.41.2 ± 1.10.3 ± 0.1
1,4404 ± 5.31.6 ± 0.32.5 ± 2.40.6 ± 0.7
  • * Mean ± SD of four patients.