Table 2.

PF-3512676–induced cytokine release measured by cytometric bead array in supernatants from 24 h-cultures of the total SLN leukocyte population (A) and supernatants from overnight anti-CD3/anti-CD28–stimulated SLN T-cell cultures (B)

(A) Total SLN leukocyte population
IL-1βIL-6IL-8IL-10IL-12p70TNFα
Saline*41 ± 3349 ± 28908 ± 3989 ± 48 ± 612 ± 5
PF-351267647 ± 31172 ± 1031,988 ± 1,10522 ± 169 ± 419 ± 6
P0.6020.0020.0220.0010.3100.009
(B) SLN T cells
IFNγ
IL-4
IL-5
IL-10
IFNγ/IL-4
IFNγ/IL-5
Saline*1,682 ± 97261 ± 8284 ± 815,528 ± 5,16945 ± 2933 ± 41
PF-35126762,597 ± 1,98344 ± 4047 ± 475,817 ± 5,17174 ± 43111 ± 119
P0.2840.8840.1910.8390.0990.002
  • * Mean ± SD (pg/mL) in the saline-administered patient population.

  • Mean ± SD (pg/mL) in the PF-3512676–administered patient population.

  • By Mann-Whitney U test.