Table 4.

Response rate and survival data by EGFR mutation status, EGFR gene copy number status, and KRAS mutation status

EGFR mutation status (tested, 71/73), n (%)
EGFR gene copy number status (tested, 59/73), n (%)
KRAS mutation status (tested, 70/73), n (%)
Wild type (n = 64)Mutant (n = 7)Not increased (n = 27)Increased (n = 32)Wild type (n = 54)Mutant (n = 16)
CR + PR2 (28.6)5 (71.4)1 (20)4 (80)7 (100)0
PD53 (96.4)2 (3.6)23 (50)23 (50)38 (70.4)16 (29.6)
SD9 (100)03 (37.5)5 (62.5)9 (100)0
P*<0.00010.480.04
Median OS, mo7.821.98.29.39.45.0
P*0.080.680.62
Median TTP, mo2.19.32.12.82.91.7
P*0.150.440.0025
  • Abbreviations: CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease.

  • * Log-rank test.