Table 3.

Correlation between LOH and hypermethylation and SMAD4C, SMAD4N, and cellular SMAD4 expression using χ2 test

Gene alterationSMAD4 (cytoplasmic staining)
SMAD4 (nuclear staining)
SMAD4
χ2 (df = 1)Pχ2 (df = 1)Pχ2 (df = 1)P
LOH4.540.033*4.870.027*7.11<0.01*
Methylation4.520.034*6.560.010*7.40<0.01*
  • * Statistically significant.