Table 4.

Summary of SMAD4 expression and genetic alterations in gastric cancer cell lines

Cell lineSMAD4 transcriptSMAD4 proteinSMAD4 methylationSMAD4 LOHSMAD4 mutation
SNU5++++NoYesNo
SNU16++++NoYesNo
SNU216+NoYesYes
SNU484+++++NoNoNo
SNU638++++++NoNoNo
MKN28+++*NoYesNo
MKN74++NoYesNo
KATOIII++++NoYesNo
AGS++*NoYesNo
  • NOTE: “−” absent; “+” weak; “++” moderate; “+++” strong.

  • * SMAD4 protein expression in MKN28 and AGS cells was evident upon extended exposure of the Western blot.