Table 1.

Clinical and molecular data of the tumor test group

Case no.Age at onset (y)Microsatellite status*MLH1 expression [IHC]Fulfilled Amsterdam criteria I or IIBethesda criteria§Pathogenic mutationBRAF V600E mutationDistal methylation (%)Proximal methylation (%)Mean value of distal and proximal methylation (%)
236101N.a.N.a.000
444101Neg.N.a.000
538101N.a.N.a.000
66610N.a.Pos.495954
745101Neg.Neg.111
97410N.a.Neg.233
106410N.a.Neg.301
117810N.a.Neg.301
1231101N.a.Neg.323
1339101N.a.Neg.201
1564101Neg.Neg.503
1637101Neg.Neg.603
177010N.a.Neg.323
2046101Neg.N.a.000
2137101Neg.N.a.000
2437101Neg.Neg.000
2537101Neg.Neg.000
2763101Neg.Neg.000
283310II1Neg.Neg.000
2948101Neg.Neg.021
3144101Neg.Neg.000
325610I1Neg.Neg.011
363710I1Neg.Neg.042
374710II1Neg.N.a.000
4060101Neg.Neg.011
4531101N.a.N.a.100
5135101Neg.Neg.253
524710I1Neg.N.a.201
5442101Neg.Neg.354
5648101Neg.Neg.302
5744101Neg.Neg.1216
586110II1Neg.Pos.265038
607710I1Neg.N.a.141916
6226101Neg.N.a.216543
6371101Neg.Pos.241921
6463101Neg.Neg.284536
65**33101Neg.Neg.326448
6647101Neg.Neg.403738
6770101Neg.Pos.415246
6866101Neg.Pos.413639
6967101N.a.Pos.5910085
719010N.a.Neg.1006382
7346101N.a.Neg.1003568
7575101N.a.Neg.886174
796610N.a.Pos.695662
828310N.a.Neg.573044
8372101N.a.Pos.543645
8486101N.a.Neg.53127
887310N.a.Pos.473843
907410N.a.Pos.391929
  • * 1, MSI-H.

  • 0, negative. IHC, immunohistochemistry.

  • —, no criterion.

  • § 1, fulfilled; −, negative.

  • Neg., negative (no sequence alteration and no deletions/amplifications detectable). N.a., not available.

  • Pos., positive; Neg., negative.

  • ** Germ-line methylation detected.