Table 2.

Most frequent aberrations in ACC

CytobandSize of region (Mbps)No. tumors, n (%)Candidate genes
Gains1p36.33-p35.327.708 (44)E2F2, TNFRSF4
1p35.2-p3316.118 (44)CSF3R, PTPRF, HDAC1
2q37.30.585 (28)
4p16.31.695 (28)FGFR3, CTBP1
5q32-q33.13.677 (39)PDGFRB
8q24.33.807 (39)PLEC1
9q33.3-q34.311.4413 (72)ABL1, NOTCH1, TRAF2
11p15.51.826 (33)MUC2, HRAS
11q13.30.3711 (61)FGF3, FGF4, FGF19
11q23.32.3011 (61)IL10RA, MLL, CBL
12q13.2-q14.11.775 (28)ERBB3, STAT6, RAB5B, WNT1
13q341.046 (33)TFDP1, GAS6
16p13.34.428 (44)MMP25, SOX8, RAB26
16q24.30.057 (39)
17p13.31.847 (39)CRK
17q11.2-q25.355.155 (28)ERBB2, PPMD1, ITGB4
19p13.3-p13.1117.9014 (78)RAB8A, FGF22, ICAM5
19q12-q13.4326.7514 (78)TGFB1, BCL3
20q13.332.645 (28)SOX18, PTK6, RTEL1, TNFRSF6B
21q22.33.2111 (61)ITGB2, PTTG1IP, COL18A1, S100B
22q13.331.2113 (72)ECGF1, MAPK12
Losses1p21.3-p1223.732 (11)ST7L
5q21.12.493 (17)ST8SIA4
5q21.3-q23.218.823 (17)APC
9p22.3-p13.320.473 (17)CDKN2A
12q12-q14.123.012 (11)KRT7, HOXC5
13q14.3-q21.3213.222 (11)PCDH17, PCDH9, INTS6
14q11.2-q31.364.524 (22)SEL1, DLG7, NFKBIA
17p13.1-q11.112.932 (11)LLGL1
20q11.23-q121.983 (17)DHX35
  • NOTE: Most frequently gained (>25%) and lost (>10%) minimal common regions of overlap were detected by array CGH in 18 primary ACCs, together with candidate oncogenes and tumor suppressor genes. The size of the aberration is depicted in mega-bps (Mbps).