Table 4.

Summary statistics of BAY 50-4798 pharmacokinetic variables

Dose (μg/kg)
StatisticsTmax (h)
Cmax (μg/L)
Cmax ratio*
AUC(0-8) (μg·h/L)
AUC(0-8) (ratio)*
Day 1Day 19Day 1Day 19Day 19/day 1Day 1Day 19Day 19/day 1
1.3n33333333
Geometric mean0.3150.31520.1846.7750.61728.47612.8930.671
SD1.491.491.544.130.501.722.360.49
%CV40.0240.0243.07141.93ND54.3585.98ND
2.6n44444444
Geometric mean0.2970.29731.96445.8291.49332.80142,2321.342
SD1.411.411.941.410.481.861.400.43
%CV34.6634.6666.4234.68ND62.2133.51ND
5.2n44444444
Geometric mean0.2970.35455.74672.6951.32076.31997.0841.557
SD1.411.491.271.210.241.161.971.26
%CV34.6640.0223.9019.10ND15.2367.97ND
10.4n2012201212201212
Geometric mean0.2680.315117.33109.431.064173.02181.941.342
SD1.241.411.551.710.301.451.970.56 ND
%CV21.3334.1344.0153.84ND37.0367.765
17.4n65655651.384
Geometric mean0.2810.250161.05140.941.005183.79201.210.51
SD1.331.001.601.320.302.001.68ND
%CV28.300.0046.8628.04ND69.2752.163
26.1n63633631.305
Geometric mean0.2500.250264.95266.561.355328.21317.360.57
SD1.001.001.791.530.721.781.52ND
%CV0.000.0057.9842.74ND57.7742.15
  • Abbreviations: ND, not determined; %CV, percentage coefficient of variation.

  • * Day 19/day 1 ratio was determined based on arithmetic means.