Table 1.

Increment factor of BxPC-3 xenograft volume at the end of treatment in the small tumor (S) experiment

mAb doseTreatmentIncrement factor*% Tumor-free mice
C8.0 ± 4.00
M4.9 ± 2.10
50T6.4 ± 4.40
T+M0.7 ± 0.525 (2/8)
C21.3 ± 7.00
M4.3 ± 2.80
200T5.5 ± 2.10
T+M0.8 ± 0.360 (3/5)
  • Abbreviations: C, control; M, matuzumab; T, trastuzumab; T+M, both mAbs.

  • * Increment factor: (tumor volume at the end of treatment) / (tumor volume at the beginning of treatment).