Clinicopathologic influences of the EGFR codon 497 polymorphism in stage II/III colorectal cancer patients receiving curative surgery
| Characteristics | G/G (wild-type), n (%) | G/A or A/A, n (%) | P |
|---|---|---|---|
| All patients | 27 (100) | 73 (100) | |
| Age (y) | |||
| <50 | 13 (48.1) | 39 (53.4) | 0.81 |
| ≥50 | 14 (51.9) | 34 (46.6) | |
| Gender | |||
| Male | 17 (63.0) | 50 (68.5) | 0.78 |
| Female | 10 (37.0) | 23 (31.5) | |
| Performance status | |||
| 0 | 18 (66.7) | 52 (71.2) | 0.84 |
| 1, 2 | 9 (33.3) | 21 (28.8) | |
| Primary tumor | |||
| Colon | 16 (59.3) | 46 (63.0) | 0.91 |
| Rectum | 11 (40.7) | 27 (37.0) | |
| Histologic differentiation | |||
| Well/moderate | 20 (74.1) | 58 (79.5) | 0.76 |
| Poorly/unknown | 7 (25.9) | 15 (20.5) | |
| Invasive extent | |||
| T1-T2 | 9 (33.3) | 47 (64.4) | 0.01 |
| T3-T4 | 18 (66.7) | 26 (35.6) | |
| Lymph node status | |||
| N0 | 11 (40.7) | 51 (69.9) | 0.02 |
| N1-N3 | 16 (59.3) | 22 (30.1) | |
| Subsequent distant metastasis | |||
| No | 6 (22.2) | 63 (86.3) | <0.01 |
| Yes | 21 (77.8) | 10 (13.7) | |
| Preoperative CEA level (ng/mL) | |||
| ≤6 | 13 (48.1) | 42 (57.5) | 0.54 |
| >6 | 14 (51.9) | 31 (42.5) | |
NOTE: According to international TNM staging system for colorectal carcinoma.
Abbreviations: G, guanine; A, adenine.