Table 1.

Clinicopathologic influences of the EGFR codon 497 polymorphism in stage II/III colorectal cancer patients receiving curative surgery

CharacteristicsG/G (wild-type), n (%)G/A or A/A, n (%)P
All patients27 (100)73 (100)
Age (y)
    <5013 (48.1)39 (53.4)0.81
    ≥5014 (51.9)34 (46.6)
Gender
    Male17 (63.0)50 (68.5)0.78
    Female10 (37.0)23 (31.5)
Performance status
    018 (66.7)52 (71.2)0.84
    1, 29 (33.3)21 (28.8)
Primary tumor
    Colon16 (59.3)46 (63.0)0.91
    Rectum11 (40.7)27 (37.0)
Histologic differentiation
    Well/moderate20 (74.1)58 (79.5)0.76
    Poorly/unknown7 (25.9)15 (20.5)
Invasive extent
    T1-T29 (33.3)47 (64.4)0.01
    T3-T418 (66.7)26 (35.6)
Lymph node status
    N011 (40.7)51 (69.9)0.02
    N1-N316 (59.3)22 (30.1)
Subsequent distant metastasis
    No6 (22.2)63 (86.3)<0.01
    Yes21 (77.8)10 (13.7)
Preoperative CEA level (ng/mL)
    ≤613 (48.1)42 (57.5)0.54
    >614 (51.9)31 (42.5)
  • NOTE: According to international TNM staging system for colorectal carcinoma.

    Abbreviations: G, guanine; A, adenine.