Table 1.

Dose escalation scheme

ScheduleDose levelVorinostat, days 1-14 (mg)Paclitaxel, day 1 (mg/m2)Carboplatin, day 1 (AUC mg/mL × min)No. patients
A1200 qd17564
2300 qd17563
3400 qd17563
4400 qd200612
B5300 bd (days 1-7)20066