Table 4.

Pharmacokinetic variables for vorinostat and metabolites on day 1 of treatment

Dose (mg)No. patientsCmax (μmol/L)Tmax (h)AUC (μmol/L × h)t1/2 (h)Clapp (L/min)
Vorinostat
    20011.450.52.41.85.2
    30081.36 ± 0.521.38 ± 0.523.54 ± 1.311.37 ± 0.425.73 ± 2.04
    400151.81 ± 0.701.27 ± 0.424.67 ± 2.331.45 ± 0.566.19 ± 1.88
Vorinostat glucuronide
    20012.8116.92.1NA
    30083.67 ± 2.092.19 ± 1.0311.7 ± 11.31.56 ± 0.21NA
    400153.62 ± 1.221.50 ± 0.3812.8 ± 7.22.08 ± 1.36NA
4-Anilino-4-oxobutanoic acid
    20013.82115.35.9NA
    30084.87 ± 1.992.75 ± 1.1327.2 ± 10.86.6 ± 5.0NA
    400155.14 ± 1.422.23 ± 1.0323.5 ± 6.94.2 ± 1.8NA
  • Abbreviations: t1/2, half-life; NA, not applicable.