Table 5.

Comparison of day 1 versus day 5 pharmacokinetic variables of vorinostat

VariableMedian, day 1Median, day 5P
Cmax (μmol/L)1.71.30.52
Tmax (h)1.51.60.085
AUC (μmol/L × h)3.85.20.011
t1/2 (h)1.32.10.012
Clapp (L/min)6.44.40.0063
  • NOTE: Cmax and Tmax are based on 17 patients; other variables are based on 16 patients.