Comparison of day 1 versus day 5 pharmacokinetic variables of vorinostat
| Variable | Median, day 1 | Median, day 5 | P |
|---|---|---|---|
| Cmax (μmol/L) | 1.7 | 1.3 | 0.52 |
| Tmax (h) | 1.5 | 1.6 | 0.085 |
| AUC (μmol/L × h) | 3.8 | 5.2 | 0.011 |
| t1/2 (h) | 1.3 | 2.1 | 0.012 |
| Clapp (L/min) | 6.4 | 4.4 | 0.0063 |
NOTE: Cmax and Tmax are based on 17 patients; other variables are based on 16 patients.