Table 5.

Association of biomarker expression with efficacy variables: best response rate and TtTP

MarkerResponse rate, P*TtTP, P*
DHFR0.5750.446
DPD0.7071.000
FPGS0.1150.019
GARFT0.5530.489
GGH0.7040.711
RFC10.7470.678
TP0.0230.076
TS0.6270.836
MTHFR0.8230.235
PKCβ0.7770.503
VEGF0.9630.489
  • * Asymptotic probability of the observed maximum χ2 statistic under the null hypothesis of no association between best study response or TtTP and marker expression level, limiting the search to the central 50% of values. Calculated with the formula of Miller and Siegmund (22).