Table 1.

Colorectal cancer incidence up to age 85 years in first-degree relatives of colorectal cancer probands (expected figures calculated from national rates from Finland)

Age of proband (y)
<55
55+
All
Age of relative (y)OESMR (95% CI)OESMR (95% CI)OESMR (95% CI)
All
    <55171.6210.47* (6.10-16.77)3314.992.20* (1.52-3.09)5016.613.01* (2.23-3.97)
    55+145.282.65 (1.45-4.45)9268.361.35 (1.08- 1.65)10673.641.44* (1.18- 1.74)
    All316.904.49* (3.05- 6.38)12583.351.50* (1.25-1.79)15690.251.73* (1.47-2.02)
MS
    <5541.323.04 (0.83-7.79)1613.291.20 (0.69-1.96)2014.611.37 (0.84-2.11)
    55+94.252.11 (0.97-4.02)7661.231.24 (0.98-1.55)8565.471.30 (1.04-1.61)
    All135.562.34 (1.24-4.00)9274.511.23 (1.00-1.51)10580.071.31 (1.07-1.59)
MSI
    <55130.3142.20* (22.48-72.17)171.709.98* (5.82-15.98)302.0114.98* (10.07-21.30)
    55+51.034.85* (1.58-11.33)167.132.24 (1.28-3.64)218.162.57* (1.59-3.93)
    All181.3413.45* (7.97-21.26)338.843.74* (2.57-5.25)5110.175.01* (3.73-6.59)
MMR carriers
    <55120.07184.61* (95.41-322.47)140.12117.65* (64.33-197.39)260.18141.30* (192.3-207.04)
    55+40.636.35 (1.73-16.25)40.3312.31* (3.35-31.51)80.968.38* (3.62-16.50)
    All160.7023.02* (13.16-37.38)180.4440.54* (24.03-64.07)341.1429.85* (20.68-41.71)
  • NOTE: SMRs with 95% CI in first-degree relatives of all probands, probands with MMR-deficient cancer, and probands possessing germ-line MSH2 or MLH1 mutations.

    Abbreviations: O, observed; E, expected.

  • * P < 0.001.

  • P < 0.01.