Table 2.

Adverse events by grade

ToxicityNo. patients with toxicity by grade (%)
Grade 1Grade 2Grade 3Grade 4Total (N = 26)
Hematologic
    Anemia17 (65)6 (23)0023 (88)
    Leukopenia3 (12)11 (42)4 (15)018 (69)
    Neutropenia07 (27)3 (12)010 (38)
    Thrombocytopenia1 (4)0001 (4)
Nonhematologic
    Fatigue21 (81)2 (8)0023 (88)
    Hyperglycemia10 (38)13 (50)0023 (88)
    Hand-foot syndrome4 (15)12 (46)5 (19)021 (81)
    Excessive tearing13 (50)6 (23)1 (4)020 (77)
    Nausea/vomiting14 (54)6 (23)0020 (77)
    Abnormal LFTs14 (54)3 (12)0017 (65)
    Diarrhea12 (46)3 (12)1 (4)016 (62)
    Nail changes2 (8)14 (54)0016 (62)
    Alopecia9 (35)6 (23)0015 (58)
    Myalgia/arthralgia12 (46)2 (8)0014 (54)
    Dyspepsia6 (23)7 (27)0013 (50)
    Mucositis5 (19)8 (31)0013 (50)
    Infection08 (31)4 (15)012 (46)
    Taste change10 (38)2 (8)0012 (46)
    Headache10 (38)00010 (38)
    Neuropathy7 (27)2 (8)009 (35)
    Chest pain3 (12)3 (12)006 (23)
    Cytokine release syndrome02 (8)1 (4)03 (12)
    Nephrolithiasis001 (4)01 (4)
  • NOTE: Highest grade of each adverse event per patient is shown.

    Abbreviation: LFT, liver function tests.