Table 1.

Bortezomib (PS-341): selected targets relevant to lung cancer (33)

ProteinProtein functionRole in lung cancerEffect of PS-341
p27KIP1Cell cycle inhibition, apoptosisTumor suppressorStabilization
p53DNA damage repair, cell cycle inhibition, apoptosisTumor suppressor, therapy resistanceStabilization
NF-κBTranscription factor, apoptosis suppressorCell survival, therapy resistanceDown-regulation
Bcl-2, Bcl-xLAntiapoptosisCell survival, therapy resistanceDown-regulation
BaxProapoptosisPromote apoptosisStabilization
Cyclin D, E, ACell cycle progressionOncogenicStabilization