Peptides from WT1 that are predicted to bind to HLA-DRB molecules
| Name | Sequence | Score* | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DRB1*0101 | DRB1*0301 | DRB1*0401 | DRB1*0701 | DRB1*1101 | DRB1*1501 | |||||||
| 423 | RSDELVRHHNMHQRNMTKL | 15 | 17 | 20 | 14 | 10 | 24 | |||||
| 328 | PGCNKRYFKLSHLQMHSRKHTG† | 28 | 11 | 28 | 18 | 25 | 20 | |||||
| 122 | SGQARMFPNAPYLPSCLES‡ | 22 | 18 | 22 | 16 | 16 | 18 | |||||
| 122A1 | SGQAYMFPNAPYLPSCLES§ | 27 | 17 | 22 | 18 | 16 | 18 | |||||
| Frequency in Caucasian population (49) | 18.5 | 17.7 | 23.6 | 26.2 | 17.0 | 19.9 | ||||||
↵* SYFPEITHI prediction software available at http://www.syfpeithi.de.
↵† Peptide encompasses the sequence reported by ref. 29 (WT1 amino acids 331-345).
↵‡ Peptide encompasses the sequence reported by Kobayashi et al. (WT1 amino acids 124-138; ref. 31).
↵§ Residue Y in bold represents a modification from the native 122 sequence.