Table 1.

Spearman rank test analyses of the array immunostainings

ProteinpAktThr308pS6EGFRpEGFRCOX-2p53
pAktSer473n = 288 (P < 0.0001)n = 288 (P < 0.002)n = 276 (P < 0.005)n = 283 (NS)n = 279 (P < 0.05)n = 273 (NS)
pAktThr308n = 301 (P < 0.0001)n = 283 (NS)n = 293 (NS)n = 290 (P < 0.005)n = 285 (NS)
pS6n = 289 (NS)n = 299 (NS)n = 295 (P < 0.0001)n = 288 (NS)
EGFRn = 289 (NS)n = 286 (P < 0.0001)n = 282 (NS)
pEGFRn = 297 (NS)n = 291 (NS)
COX-2n = 290 (NS)
  • NOTE: The values represent number of common cores analyzed (n) and P values. Strong correlation is seen between the proteins of the Akt-mTOR pathway, independently of the status of activation of EGFR. p53 behaves as an independent variable, showing no correlation with the other proteins analyzed.

    Abbreviation: NS, not significant.