Table 3.

SS1P pharmacokinetics

Dose (μg/kg/dose)No. patientsCmax (ng/mL)AUC0-t (μg/mL min)t 1/2 (min)
83191124447
123317173377
185338331709
258442343827
353330372773
459483292466
602602279309
  • NOTE: Mean SS1P Cmax, AUC0-t, and t 1/2 after C1D1 infusion. Pharmacokinetic data of patients treated with SS1P at 25 μg/kg/dose on the QOD × 6 schedule or QOD × 3 schedule have been combined for analysis. Similarly, pharmacokinetic data from patients treated with SS1P at a dose level of 45 μg/kg/dose with or without prednisone have been combined.