Expression and function of the B7 family ligands and their receptors of the CD28 family
The B7 family ligands | The CD28 family receptors | ||||
---|---|---|---|---|---|
Expression | Name | Name | Expression | Function | |
Group I | |||||
APC | B7-1 | ![]() | CD28 | T cells | Costimulation |
APC | B7-2 | CTLA-4 | Activated T cells | Coinhibition | |
APC, tissue | B7h | ![]() | ICOS | Activated T cells | Costimulation |
Group II | |||||
APC, tissue, tumors | PD-L1 | ![]() | PD-1 | Activated T, B, and myeloid cells | Coinhibition |
APC | PD-L2 | ![]() | PD-1 | Activated T, B, and myeloid cells | Coinhibition |
Group III | |||||
APC, tissue, tumors | B7-H3 | ![]() | Unidentified receptor | Activated T cells | Coinhibition |
Tissue, tumors | B7x | ![]() | Unidentified receptor | Activated T cells | Coinhibition |