Table 1.

Preventive/therapeutic agents and their mechanism of action

AgentMechanism of action
Hormone related
    TamoxifenAntiestrogen/estrogen
    VorozoleAromatase inhibitor
    OvariectomyRemoval of estrogen source
Targeted agents
    R-115777Farnesyltransferase inhibitor
    IressaEpidermal growth factor receptor inhibitor
RXR agonists
    9cRARetinoic acid receptor/RXR agonist
    UAB30RXR agonist
    TargretinRXR agonist
Phase I/II inducers
    5,6-BenzoflavoneSynthetic phase I/II inducer
    Indole-3-carbinolPlant derived phase I/II inducer
    DiindoylmethaneMetabolite of indole-3-carbinol
COX 1/2 inhibitors
    SulindacCOX 1/2 inhibitor
    CelecoxibCOX 2 inhibitor
Various
    MeclizineH2 antagonist
    Sodium phenylbutyrateHistone deacetylase inhibitor
    Vitamin CAntioxidant