Table 2.

Differential analysis of genes involved with eicosanoid metabolism in BP, MP, and tumor tissue from EOC patients

Gene symbolGene nameTwo-sample t test (P < 0.05)
Parametric P value
Permutation P value
BP/MPMP/TUBP/TUBP/MP/TU(10,000)
AKR1C3Aldo-keto reductase family 1, member C30.71930.00020.00900.00030.000
ALOX12Arachidonate 12-LOX0.72100.19330.13720.21390.219
ALOX15BArachidonate 15-LOX, type B0.08450.32040.40560.28090.282
ALOX5Arachidonate 5-LOX0.28510.24130.98390.39560.394
ALOX5APArachidonate 5-LOX-activating protein0.49680.25940.16210.28070.274
CBR1Carbonyl reductase 10.95210.65000.68450.87250.865
CBR3Carbonyl reductase 30.34500.07520.01140.03560.035
COX7A1Cytochrome c oxidase subunit VIIa polypeptide 1, muscle0.47680.00000.00150.00000.000
CYP2B6Cytochrome P450, family 2, subfamily B, polypeptide 60.57700.55520.30430.58000.574
CYP2C8Cytochrome P450, family 2, subfamily C, polypeptide 80.81740.15940.12480.20960.211
CYP2C9Cytochrome P450, family 2, subfamily C, polypeptide 90.57790.84130.60530.78280.791
CYP2E1Cytochrome P450, family 2, subfamily E, polypeptide 10.26870.31360.83110.40990.416
CYP2J2Cytochrome P450, family 2, subfamily J, polypeptide 20.00040.00230.00000.00000.000
CYP4A11Cytochrome P450, family 4, subfamily A, polypeptide 110.90580.94660.8511N/AN/A
CYP4F2Cytochrome P450, family 4, subfamily F, polypeptide 20.07270.09950.49000.09160.092
CYP4F3Cytochrome P450, family 4, subfamily F, polypeptide 30.51360.31540.88700.61930.627
EPHX1Epoxide hydrolase 1, microsomal (xenobiotic)0.84150.38710.35020.55590.553
EPHX2Epoxide hydrolase 2, cytoplasmic0.52890.91730.45910.72850.741
FBXL7F-box and leucine-rich repeat protein 70.71340.00000.00250.00000.000
GGT1γ-Glutamyltransferase 10.64760.05650.35920.21290.215
GGTLA1γ-Glutamyltransferase-like activity 10.53080.79160.40560.71540.727
GPX1Glutathione peroxidase 10.45290.93420.53330.76240.766
GPX2Glutathione peroxidase 2 (gastrointestinal)0.45640.61540.21400.52650.524
GPX3Glutathione peroxidase 3 (plasma)0.07960.00350.00000.00010.000
GPX4Glutathione peroxidase 4 (phospholipid hydroperoxidase)0.99540.06070.23670.15540.154
LTA4HLeukotriene A4 hydrolase0.79200.82800.9303N/AN/A
LTC4SLeukotriene C4 synthase0.03690.20780.35290.15360.154
LYPLA3Lysophospholipase 3 (lysosomal PLA2)0.00330.00500.87110.00710.006
PGDSProstaglandin D2 synthase, hematopoietic0.25090.00240.12650.00740.007
PLA2G12APLA2, group XIIA0.08630.33680.47690.40180.396
PLA2G1BPLA2, group IB (pancreas)0.21820.59930.32380.26830.264
PLA2G2APLA2, group IIA (platelets, synovial fluid)0.08000.00000.00260.00000.000
PLA2G4APLA2, group IVA0.23090.13600.93870.26040.267
PLA2G4CPLA2, group IVC0.15120.00010.00000.00000.000
PLA2G5PLA2, group V0.97470.05570.07910.11790.117
PLA2G6PLA2, group VI0.28470.00000.00010.00000.000
PLA2R1PLA2 receptor 1, 180 kDa0.60620.00020.01430.00060.001
PLCB1Phospholipase C, β1 (phosphoinositide-specific)0.55880.55840.92210.78290.777
PPARGPeroxisome proliferative-activated receptor, γ0.91740.00010.00090.00000.000
PTGER2Prostaglandin E receptor 2 (subtype EP2), 53 kDa0.89150.24440.31400.44840.457
PTGER3Prostaglandin E receptor 3 (subtype EP3)0.45100.00000.00140.00000.000
PTGER4Prostaglandin E receptor 4 (subtype EP4)0.76450.08150.24830.22060.223
PTGESProstaglandin E synthase0.63770.84190.72550.87710.883
PTGFRProstaglandin F receptor (FP)0.63460.00000.00000.00000.000
PTGIRProstaglandin I2 (prostacyclin) receptor (IP)0.35180.01570.00390.00480.006
PTGISProstaglandin I2 (prostacyclin) synthase0.46890.00010.00940.00020.000
PTGS2Prostaglandin-endoperoxide synthase 20.94210.09930.11800.15210.154
TBXA2RThromboxane A2 receptor0.79270.93880.7286N/AN/A
TBXAS1Thromboxane A synthase 10.80300.03450.08810.07600.078
  • NOTE: P values showing significant differential down-regulation (italics) and up-regulation (boldface).