Table 2.

Modulating effect of p53 intron 6, p27 5′ UTR, CCND1 G870A, and STK15 F31I genotypes on lung cancer risk by smoking intensity

Smoking intensityGenotypep53 intron 6
p27 5′ UTR
CCND1 G870A
STK15 F31I
Cases/controlsOR (95% CI)*Cases/controlsOR (95% CI)Cases/controlsOR (95% CI)Cases/controlsOR (95% CI)
NeverGenotype 1163/128Reference61/80Reference164/136Reference174/151Reference
Genotype 248/410.91 (0.56-1.47)63/461.83 (1.10-3.15)46/351.06 (0.64-1.74)7/41.08 (0.69-1.67)
LightGenotype 1279/380Reference114/160Reference307/409Reference325/394Reference
Genotype 2114/1221.27 (0.94-1.72)76/1150.94 (0.65-1.38)77/911.11 (0.79-1.56)7/210.87 (0.64-1.17)
HeavyGenotype 1514/452Reference149/129Reference535/469Reference566/369Reference
Genotype 2206/1221.48 (1.15-1.89)123/791.35 (0.93-1.95)161/1011.40 (1.06-1.84)25/230.98 (0.75-1.28)
  • * Adjusted for age, gender, and smoking status.

  • Genotype 1: WW for p53 intron 6 and p27 5′ UTR, WW+WM for CCND1 G870A and STK15 F31I; Genotype 2: WM+MM for p53 intron 6 and p27 5′ UTR, MM for CCND1 G870A and STK15 F31I (WW, common homozygotes; WM, heterozygotes; MM, rare homozygotes).