Table 3.

Modulating effect of smoking intensity on lung cancer risk by p53 Intron 6, p27 5′ UTR, CCND1 G870A, and STK15 F31I genotypes

Genotypep53 Intron 6
p27 5′ UTR
CCND1 G870A
STK15 F31I
Cases/controlsOR (95% CI)Cases/controlsOR (95% CI)Cases/controlsOR (95% CI)Cases/controlsOR (95% CI)*
WW
    Light279/379Reference114/159Reference119/142Reference214/252Reference
    Heavy514/4521.52 (1.24-1.87)149/1291.54 (1.09-2.19)191/1871.24 (0.89-1.71)375/2471.83 (1.42-2.35)
WM
    Light110/107Reference65/98Reference188/266Reference111/141Reference
    Heavy190/1151.61 (1.13-2.31)102/712.05 (1.31-3.21)344/2821.68 (1.31-2.16)191/1221.88 (1.33-2.66)
MM
    Light4/15Reference11/17Reference77/91Reference7/21Reference
    Heavy16/78.65 (2.01-37.17)21/86.24 (1.67-23.34)161/1011.88 (1.25-2.83)25/232.94 (1.03-8.39)
  • Abbreviations: WW, common homozygotes; WM, heterozygotes; MM, rare homozygotes.

  • * Adjusted for age, gender, and smoking status.