Table 4.

Combined effects of adverse alleles in the cell cycle control pathway on lung cancer risk

No. adverse allelesCases (n)/controls (n)OR (95% CI)*
Overall
    ≤151/75Reference
    2102/1011.53 (0.97-2.41)
    ≥3362/3471.59 (1.07-2.34)
    Ptrend0.041
Age
    <62 y
        ≤128/37Reference
        254/471.48 (0.79-2.79)
        ≥3163/1711.25 (0.73-2.14)
        Ptrend0.688
    ≥62 y
        ≤123/38Reference
        248/541.63 (0.84-3.19)
        ≥3199/1762.08 (1.17-3.70)
        Ptrend0.011
Gender
    Male
        ≤130/38Reference
        256/501.52 (0.81-2.85)
        ≥3188/1531.57 (0.92-2.68)
        Ptrend0.147
    Female
        ≤121/37Reference
        246/511.61 (0.82-3.15)
        ≥3174/1941.61 (0.91-2.86)
        Ptrend0.171
Smoking status
    Never smokers
        ≤111/13Reference
        224/241.19 (0.44-3.21)
        ≥376/741.22 (0.51-2.91)
        Ptrend0.691
    Ever smokers
        ≤140/62Reference
        278/771.60 (0.96-2.67)
        ≥3286/2731.68 (1.09-2.58)
    Ptrend0.037
Smoking intensity
    Light smokers (pack-years <39)
        ≤130/44Reference
        258/681.26 (0.70-2.26)
        ≥3191/2321.22 (0.74-2.02)
        Ptrend0.559
    Heavy smokers (pack-years ≥39)
        ≤121/31Reference
        244/332.07 (1.00-4.28)
        ≥3171/1152.23 (1.21-4.11)
        Ptrend0.020
  • * Adjusted for age, gender, smoking status, and pack-years for the overall analysis; adjusted for age, gender, and pack-years for the analysis stratified with smoking status; adjusted for age, gender, and smoking status for the analysis stratified with pack-years; adjusted for age, smoking status, and pack-years for the analysis stratified with gender; and adjusted for gender, smoking status, and pack-years for the analysis stratified with age.

  • The median age of control subjects is 62 y.