Table 3.

Patients in the i.v. arm with grade 3/4 treatment-emergent adverse events

EventPatients, n (%)
0.04 mg/kg (n = 3)0.16 mg/kg (n = 3)0.32 mg/kg (n = 7)0.48 mg/kg (n = 6)
Deep venous thrombosis1 (33)*
Vein compression1 (33)*
Anemia1 (14)
Leukopenia1 (14)
Lymphopenia1 (14)
Neutropenia1 (14)1 (17)
Adverse drug reaction1 (14)
Insomnia1 (14)
Diarrhea1 (33)*
Dehydration1 (33)*
Vomiting1 (33)*
  • * Serious adverse event.

  • Dose-limiting toxicity.