Table 2.

Cox proportional hazards analysis for time to PSA recurrence

VariableUnivariate* (all patient, n = 192)Multivariate* (all patients, n = 172)
Univariate* (low Gleason§, n = 112)Multivariate* (low Gleason, n = 103)
Univariate* (high Gleason, n = 80)Multivariate* (high Gleason, n = 69)
ContinuousDichotomizedContinuousDichotomizedContinuousDichotomized
Gleason score >7<0.00010.00110.0014NANANANANANA
3.70 (2.23-6.11)2.81 (1.51-5.24)2.80 (1.49-5.26)
Seminal vesicle invasion (stage = pT3b)<0.00010.00350.00320.00650.037**0.00860.0120.0089
4.10 (2.47-6.81)2.46 (1.35-4.51)2.46 (1.35-4.47)5.52 (1.61-18.89)4.07 (1.09-15.20)2.21 (1.22-3.98)2.36 (1.21-4.60)2.45 (1.25-4.80)
Capsular invasion0.00380.0190.0360.0140.0049**0.420.520.69
1.73 (1.19-2.52)1.67 (1.09-2.57)1.55 (1.03-2.35)2.21 (1.17-4.16)3.08 (1.41-6.73)1.23 (0.75-2.04)1.20 (0.69-2.09)1.11 (0.66-1.86)
Preoperative PSA0.0150.600.700.0240.011**0.950.840.67
1.02 (1.00-1.03)††1.00 (0.99-1.02)1.00 (0.99-1.02)1.04 (1.01-1.07)‡‡1.04 (1.01-1.08)1.00 (0.98-1.02)§§1.00 (0.98-1.02)1.00 (0.98-1.02)
XIAP intensity (continuous)∥∥0.0330.077NA0.0280.17NA0.250.19NA
1.54 (1.04-2.29)1.49 (0.96-2.33)2.20 (1.09-4.44)1.85 (0.77-4.43)1.33 (0.82-2.17)1.42 (0.84-2.41)
XIAP intensity ≤1.8 (dichotomized)¶¶0.0010NA0.0025**NA**0.011NA0.010
10.69 (2.61-43.73)8.92 (2.16-38.86)6.37 (1.54-26.43)6.61 (1.57-27.89)
  • * P value; hazard ratio; (95% confidence interval) provided.

  • 64% of cases are censored.

  • 67% of cases are censored.

  • § Gleason score 2 to 6; 79% of cases are censored.

  • Gleason score 2 to 6; 83% of cases are censored.

  • Gleason score 7 to 9 (no Gleason score 10 cases are present); 43% of cases are censored.

  • ** High XIAP group has no events (all patients are censored).

  • †† n = 172.

  • ‡‡ n = 103.

  • §§ n = 69.

  • ∥∥ Pooled mean XIAP intensity. Used formula (3–continuous XIAP intensity) to reverse hazard ratio to compare directly to other covariates. A high XIAP carries a reduced risk of recurrence.

  • ¶¶ Pooled mean XIAP intensity dichotomized: ≤1.8 (n = 158); >1.8 (n = 34).